In Focus
In Focus: Cryogenic containment for cell and gene therapies
The complex manufacturing processes of cell and gene therapies often require extremely low temperatures. This requires cryogenic containers, which allow for the storage and ...
Read moreIn Focus: Scalability
Cell expansion allows researchers and cell therapy developers to generate the necessary quantity of cells for their applications. However, cell expansion comes with several challenges, ...
Read moreIn Focus: Expansion and downstream processing of hiPSCs
Human induced pluripotent stem cells (hiPSCs) hold immense promise for widespread cell therapies, but scaling their production for clinical use is a major obstacle. A novel solution ...
Read moreIn Focus: Automating cell expansion
In this In Focus feature, we’re investigating cell culture expansion processes and how to automate them in a system that replicates the physiological environment. Cell culture and ...
Read moreIn Focus: GMP-grade cell culture
Good manufacturing practice (GMP) encompasses a set of quality control and assurance standards that ensure products used in various biopharmaceutical and biotechnological applications ...
Read moreIn Focus: Small molecules
Small molecules can be used throughout the development of induced pluripotent stem-cell derived cell therapies for reprogramming, maintenance and differentiation. But it can often be ...
Read moreIn Focus: AI for cell culture imaging and analysis
Live cell imaging and analysis is a major component of cell therapy development, allowing measurement of critical factors such as cell proliferation, cellular kinetics, protein ...
Read moreIn Focus: Raw materials
As cell therapies progress from the lab to the clinic, the raw material requirements change. In the clinical and commercial stages they need to meet higher safety and quality conditions ...
Read moreIn Focus: Growing organoids
Organoids are three-dimensional, miniaturized tissue constructs that can be generated from pluripotent stem cells, adult stem cells, or primary tissues and closely mimic the ...
Read moreIn Focus: CAR-T cell therapy
Despite the great clinical success of CAR-T therapies, due to their complexity manufacturers continue to face a number of challenges, including contamination, variability and cost. In ...
Read moreIn Focus: iPSCs for cell therapy
With their unlimited proliferation capacity and ability to differentiate into nearly any cell type in the body, induced pluripotent stem cells (iPSCs) have the potential to provide an ...
Read moreIn Focus: cell culture quality control
Cell culture quality control is a critical step for the development, manufacture and commercialization of any cell-based therapy. However, it is a time-consuming and labor-intensive ...
Read moreIn Focus: automated process
In the manufacturing of cell therapies, fill and finish is a critical, high-value step for ensuring final products are safe, efficacious and standardized. Fill and finish is a highly ...
Read moreIn Focus: Reagent consistency
How can cell therapy manufacturers guarantee consistent, high-quality results for their final products? In this In Focus feature, we are diving deep into the topic of reagent ...
Read moreIn Focus: scaling up and out
The cell and gene therapy industry has undergone remarkable advances in the last decade, bringing life-saving treatments to patients with diseases that were originally thought to be ...
Read moreIn Focus: sustainability in cell and gene therapy
The advanced therapies and pharmaceuticals industry are under constant pressure to innovate. With the common goal of bringing life-saving treatments to patients, the industry often ...
Read moreIn Focus: electroporation
Transfection is the process of introducing foreign material – generally nucleic acids (DNA or RNA) – into cells. This allows for the study of gene function and protein ...
Read moreIn Focus: AAV gene therapy
Adeno-associated viruses (AAVs) are rapidly becoming a promising means of delivering gene therapies to defective tissues in the human body. To this end, scalable and cost-effective AAV ...
Read moreIn Focus: decentralized manufacturing
Decentralized manufacturing, also referred to as ‘redistributed manufacturing’, divides the manufacturing capacity for cell and gene therapies between multiple sites. This strategy can ...
Read moreIn Focus: cell cryopreservation and cold chain
When thinking about the commercial and clinical development of cell therapies, cryopreservation and cold chain processes are essential elements to consider. Optimizing the cold chain ...
Read moreIn Focus: cellular starting materials for cell therapies
Cellular starting materials are a crucial aspect in the development of cell therapies. However, starting materials that involve a cell preparation can be a significant source of ...
Read moreIn focus: packaging and producer cell lines
Lentiviral vectors are often a popular choice for transient transfection when it comes to developing cell therapies. However, this method can often be expensive, difficult to reproduce ...
Read moreIn focus: cryopreservation
From raw materials to the finished product, cryopreservation touches every stage of the cell therapy production process. What should you consider when validating your cryopreservation ...
Read moreIn focus: applications in cardiology
The use of 3D printing in cardiology has grown over recent years, from scientists working to fabricate cardiac tissues with bioprinting techniques to surgical teams 3D printing complex ...
Read moreIn focus: the additive response to COVID-19
In the face of the COVID-19 pandemic, innovators are finding novel ways to apply 3D-printed solutions to assist the international response to coronavirus. From meeting PPE demands to ...
Read moreIn focus: nanomedicine in organ transplantation and regenerative surgery
This month, we’ve partnered with the journal Nanomedicine to bring you a special editorial in focus looking at the role nanomedicine can play in organ transplantation and ...
Read moreIn focus: raw materials
This month, we are focusing on the challenges in selecting and securing your raw materials; access an exclusive infographic, journal content and more! The consistent manufacture of cell ...
Read moreIn focus: the regenerative medicine landscape in Asia
This month, we are focusing on regenerative medicine developments, progress and regulations across Asia; access exclusive infographics, journal content and more! The regenerative ...
Read moreIn focus: applications in neuro R&D
Hear from the experts as 3DMedNet discusses the use of 3D printing in neuro-based disciplines, from the bioprinting of neural tissues to the use of 3D printing in affordable ...
Read moreIn focus: embryonic stem cells
This month, we are focusing on embryonic stem cells; access exclusive interviews, infographics, journal content and more. Embryonic stem cells (ESCs) were first cultured in 1981 and ...
Read moreIn focus: applications in pediatrics
Find out more about 3D printing in pediatrics as 3DMedNet invites the experts, from pharmaceutical design to surgery, to discuss how 3D printing is being used to solve complex pediatric ...
Read moreIn focus: disrupting dentistry
Discover expert and industry insights on the effect 3D printing is having on dentistry, disrupting dental practice and improving oral health. 3D printing technologies have had a ...
Read moreIn focus: applications in oncology
In this feature, 3DMedNet consults oncology experts about how 3D printing is being used to revolutionize cancer detection, treatment and research. According to statistics on the World ...
Read moreIn focus: regenerative pharmacology
This month, we are focusing on regenerative pharmacology; access exclusive interviews, infographics, journal content and more, in partnership with RxNet, the network for pharma R&D. ...
Read moreIn focus: regenerative materials
This month, we are focusing on regenerative materials; access exclusive interviews, videos, journal content and more. Regenerative materials offer a controlled and directed method of ...
Read moreAward for Cultivating Excellence 2018: BellaSeno GmbH
In this feature, learn more about our fantastic 2018 winners, BellaSeno GmbH, and learn more about the rest of our finalists. In this feature, learn more about our fantastic 2018 ...
Read moreIn focus: cell therapy development
This month, we are focusing on cell therapy development; access exclusive interviews, infographics, journal content and more. Successful cell therapy development involves a number of ...
Read moreLow Vision Awareness Month 2018
With this exclusive content, find out more about what lessons can be learned from the Japanese first-in-human age-related macular degeneration trial. For Low Vision Awareness Month ...
Read moreIn focus: rare diseases
Check out this round-up of top content for Rare Disease Day 2018! In honor of Rare Disease Day 2018, we’ve collated some of our top content highlighting how regenerative medicine ...
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