Convergence of gene and cell therapy
In this expert focus, originally published in Regenerative Medicine, Alexey Bersenev and Bruce Levine discuss the advantages of combining cell and gene therapy, and what potential developments the future could hold.
Gene therapy and cell therapy have followed similar roller coaster paths of rising public expectations and disappointment over the past two decades. There is now reason to believe that momentum in the field has reached the point where the successes will be more frequent. The use of gene-modified cells has opened new avenues for engineering desired cell properties, for the use of cells as vehicles for gene delivery, and for tracking cells and controlling cell persistence after transplantation. Some notable recent clinical developments in cellular engineering by gene transfer offer lessons on how the field has emerged, and hint at additional future clinical applications.