Restoring the cornea from limbal stem cells

Free to access editorial from the January Regenerative Medicine issue by Markus Frank and Natasha Frank

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Jan 29, 2015

“ light of the result that ABCB5 helps to amplify a PAX6-positive limbal stem cell will now be important to test whether ABCB5 selection could also enhance the conversion of skin epithelial stem cells to corneal epithelial stem cells.”

Corneal disease due to limbal stem cell (LSC) deficiency (LSCD) is a major cause of blind-ness worldwide. Recently, the ATP-binding cassette transporter ABCB5 was shown to be required for normal LSC function in corneal development and repair. Moreover, ABCB5 was found to serve as a unique molecular marker allowing for prospective isolation of pure LSC populations from human tissue with the exclusive capacity to fully restore the cornea in preclinical models of LSC deficiency. These results and additional recent advances in this field suggest that therapeutic use of molecularly defined corneal epithelial stem cell populations derived from limbus or skin might optimize chances for successful clinical transplants.

by Markus Frank and Natasha Frank

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Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (, where you can find the aims and scope of the journal and details of our international editorial board.

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