Regenerative medicine in lower limb reconstruction

This Open Access review evaluates current applications of bone tissue engineering techniques in limb reconstruction and identifies potential strategies for future work.

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Nov 19, 2018

Bone is a highly specialized connective tissue and has a rare quality as one of the few tissues that can repair without a scar to regain pre-injury structure and function. Despite the excellent healing capacity of bone, tumor, infection, trauma and surgery can lead to significant bone loss requiring skeletal augmentation. Bone loss in the lower limb poses a complex clinical problem, requiring reconstructive techniques to restore form and function.

In the past, amputation may have been the only option; however, there is now an array of reconstructive possibilities and cellular therapies available to salvage a limb. In this Open Access review, published in Regenerative Medicine, Josephine K McEwan et al evaluate current applications of bone tissue engineering techniques in limb reconstruction and identify potential strategies for future work.

Figure 1. Primary and secondary bone healing.
(A) Fibula fracture (see arrow). (B) Fibula fracture healed by primary bone healing following open reduction internal fixation (see arrow). (C) Tibia and fibula fracture. (D) Tibia and fibula fracture healed by secondary bone healing with callus formation (see bracket).

McEwan JK, Tribe HS, Jacobs N et al. Regenerative medicine in lower limb reconstruction. Regen.Med. 13(4), 477–490 (2018)

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Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (, where you can find the aims and scope of the journal and details of our international editorial board.

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