Research Article: Comparative bone tissue integration of nanostructured and microroughened dental implants

An overarching theme of the Nanomedicine Special Focus Issue on ‘Engineering the nanoenvironment for regenerative medicine’ is the regulation of cellular function through nanotopographical modification. The role of nanotopographical modification in osteointegration is further described by Salou et al. who present a comparison of osteointegration, who examined nanostructured implants relative to a microsurface widely used for titanium dental implants.

Go to the profile of Nanomedicine
Apr 07, 2015
0
0

Aim: The aim was to compare osteointegration of nanostructured implants to a microsurface widely used for titanium dental implants. Materials & methods: Commercial titanium dental implants with smooth or microroughened surfaces were nanostructured. Implants were inserted into the femoral condyles of rabbits. After 2 and 4 weeks, histomorphometry calculation was performed. Results: Nanotubes measuring 60 nm in diameter were observed on both S-NANO (roughness: 0.05 μm) and R-NANO (roughness: 0.40 μm) surfaces. The MICRO surface exhibited typical random cavities (roughness: 2.09 μm). At 4 weeks, bone-to-implant contact values were significantly higher for the R-NANO than for the MICRO surface while no differences were observed at 2 weeks. Conclusion: Overall, this study shows that the nanostructured surfaces improved osteointegration similar or higher than the MICRO.

Please visit Nanomedicine online to view the article.

Nanomedicine is also on Twitter: follow us @fsgnnm now!

Author affiliations:

Laëtitia Salou

Inserm U957, Lab. Pathophysiology of Bone Resorption, Faculty of Medicine, University of Nantes, France

Alain Hoornaert

CHU Nantes, Faculty of Dental Surgery, Nantes, France

Julien Stanovici

Inserm U957, Lab. Pathophysiology of Bone Resorption, Faculty of Medicine, University of Nantes, France

Sylvain Briand

Inserm U957, Lab. Pathophysiology of Bone Resorption, Faculty of Medicine, University of Nantes, France

Guy Louarn

CNRS – Institut des Matériaux, Nantes, France

Pierre Layrolle

Inserm U957, Lab. Pathophysiology of Bone Resorption, Faculty of Medicine, University of Nantes, France

Go to the profile of Nanomedicine

Nanomedicine

Journal, Future Science Group

Nanomedicine (Impact Factor: 4.889 [2015]), is an award-winning peer-reviewed journal from Future Science Group, available in both print and online formats. Published 24 times per year, Nanomedicine is a uniquely medicine-focused journal, addressing the important challenges and advances in medical nanoscale-structured material and devices, biotechnology devices and molecular machine systems and nanorobotics, delivering this essential information in concise, clear and attractive article formats. Nanomedicine is listed by Medline/PubMed, Science Citation Index Expanded, Journal Citation Reports/Science Edition, Current Contents/Life Sciences and the Biotechnology Citation Index. Professor Kostas Kostarelos (Nanomedicine Lab, University of Manchester, UK) and Professor Charles R Martin (University of Florida, FL, USA) are the journal’s Senior Editors. You can find out more about Nanomedicine on our website (http://www.futuremedicine.com/loi/nnm), including the journal’s aims and scope and details of our international editorial board.

No comments yet.