Ex vivo tumor culture systems for functional drug testing and therapy response prediction

In this Future Science OA review, learn more about different models for drug testing and how to select the most suitable one for your application.

Jan 30, 2018
"Selecting the right model system for the right purpose is at least as important as developing new and improved culture systems"

Optimal patient stratification is of utmost importance in the era of personalized medicine. Prediction of individual treatment responses by functional ex vivo assays requires model systems derived from viable tumor samples, which should closely resemble in vivo tumor characteristics and microenvironment. This review discusses a broad spectrum of model systems, ranging from classic 2D monolayer culture techniques to more experimental ‘cancer-on-chip’ procedures. 

Find out more: “Different culture systems for different purposes”: an interview with Dik van Gent

Meijer TG, Naipal KAT, Jager A, van Gent DC. Ex vivo tumor culture systems for functional drug testing and therapy response prediction. Future Sci. OA. 3(2), FSO190 (2017)

Future Science OA

Open Access Journal, Future Science Group

Future Science OA is an online, open access (CC-BY), peer-reviewed title from Future Science Group. The journal’s broad coverage includes all areas of biotechnology and medicine, as well as topics in biological, life and physical sciences that are of relevance to human health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of medical science. All original research articles that have been conducted with scientific rigor and research integrity will be considered. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis.

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