This channel presents the latest breakthroughs in bench side regenerative medicine and stem cell research, from the development of biomaterials to cell characterization. This will include the latest news as well as select journal articles.
Research Article: Human mesenchymal stem cell behavior on femtosecond laser-textured Ti-6Al-4V surfaces
An overarching theme of the Nanomedicine Special Focus Issue on ‘Engineering the nanoenvironment for regenerative medicine’ is the regulation of cellular function through nanotopographical modification. The role of nanotopographical modification in the osteointegration of titanium and titanium alloys is further explored by Cunha et al. who investigate ultrafast laser-surface texturing as a surface treatment of Ti-6Al-4V alloy dental and orthopedic implants to improve the osteoblastic commitment of human mesenchymal stem cells.
Research Article: Antibacterial and osteogenic stem cell differentiation properties of photoinduced TiO2 nanoparticle-decorated TiO2 nanotubes
An overarching theme of the Nanomedicine Special Focus Issue on ‘Engineering the nanoenvironment for regenerative medicine’ is the regulation of cellular function through nanotopographical modification. In this article, Liu et al. present research on the fabrication of titania nanotubes anodized into titanium and how these may be employed to improve the materials antibacterial and cell compatibility properties. Specifically the authors show that these surfaces induce significant downregulations in glycosytransferase genes in Streptococcus mutans populations and improved osteogenic functions in human stem cells, noting that this may provide a powerful methodology to improve orthopedic and dental implant efficacy.