Case Studies: Scaling Cell Therapy Manufacturing

This webinar is no longer available. Gain insights into T-cell expansion, viral vector production and scaling production of mesenchymal stem cells (MSCs) through the use of a functionally closed, automated, cell culture process.

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Aug 16, 2016
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This webinar is no longer available.

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Gain insights into T-cell expansion, viral vector production and scaling production of mesenchymal stem cells (MSCs) through the use of a functionally closed, automated, cell culture process.

Dr. Beltzer (Terumo BCT, CO, U.S.) will present a number of case studies to describe how process development and economic goals were achieved in both industry and academic settings.

Results include up to a 500-fold expansion of T-cells in 12 days, 40 percent reduction in cost of goods for an allogeneic cell therapy, and automated viral vector production with titers similar to flask-based processes.

Particular attention will be directed toward the process changes often needed to meet these goals.

What will you learn?

  • New results of T-cell expansion using a hollow-fiber bioreactor system
  • Techniques for scaling production of mesenchymal stem cells (MSCs)
  • New approach to viral vector production
  • Case studies on cost and labor savings achieved

Who may this interest?

  • Clinicians, researchers, lab technologists and cell therapy industry professionals
  • Cell therapy manufacturing professionals
  • Gene and immunotherapy manufacturing professionals

Speaker

Jim Beltzer, PhD
Senior Cell Processing Specialist
Terumo BCT

Prior to joining the Cell Processing team at Terumo BCT, Dr Beltzer was the lead scientist for the research and development of Corning® Synthemax®, a synthetic growth surface for the culture of human embryonic stem cells at Corning Life Sciences. He was a co-founder of RETT Corporation and was a key player in the industrialization of several technology platforms, including phage display and yeast two-hybrid. He has more than 20 years of industrial research and development experience in a broad range of disciplines.

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1 Comments

Go to the profile of Alexandra Thompson
Alexandra Thompson about 2 years ago

More cell expansion information can be found here https://www.regmednet.com/users/5333-terumo-bct/posts/4556-successful-scaling-of-cell-therapy-manufacturing-while-achieving-a-40-cog-reduction and generally in our manufacturing channel here https://www.regmednet.com/channels/83-manufacturing