Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers

Research Article by Roland Assi et al. (Yale University School of Medicine, New Haven, CT, USA) hypothesizing that the delivery of MSCs in a biomimetic collagen scaffold may improve wound healing in a diabetic mouse model.

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Oct 05, 2016
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MSCs are a promising source of cells for multiple regenerative processes. The extracellular matrix plays a significant role in controlling cell behavior, directly and indirectly modulating stem cell functions including self-renewal and differentiation. This Research Article by Roland Assi, Trenton R Foster, Hao He, Katerina Stamati, Hualong Bai, Yuegao Huang, Fahmeed Hyder, Douglas Rothman, Chang Shu, Shervanthi Homer-Vanniasinkam, Umber Cheema and Alan Dardik looks at the utilization of compressed collagen scaffolds to deliver MSCs into mouse models of diabetic wounds to determine their therapeutic potential in this translationally relevant model.

Assi R, Foster TR, He H et al. Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers. Regen. Med. 11(3), 245–260 (2016).

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Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (, where you can find the aims and scope of the journal and details of our international editorial board.

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