Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers
Research Article by Roland Assi et al. (Yale University School of Medicine, New Haven, CT, USA) hypothesizing that the delivery of MSCs in a biomimetic collagen scaffold may improve wound healing in a diabetic mouse model.
MSCs are a promising source of cells for multiple regenerative processes. The extracellular matrix plays a significant role in controlling cell behavior, directly and indirectly modulating stem cell functions including self-renewal and differentiation. This Research Article by Roland Assi, Trenton R Foster, Hao He, Katerina Stamati, Hualong Bai, Yuegao Huang, Fahmeed Hyder, Douglas Rothman, Chang Shu, Shervanthi Homer-Vanniasinkam, Umber Cheema and Alan Dardik looks at the utilization of compressed collagen scaffolds to deliver MSCs into mouse models of diabetic wounds to determine their therapeutic potential in this translationally relevant model.
Assi R, Foster TR, He H et al. Delivery of mesenchymal stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcers. Regen. Med. 11(3), 245–260 (2016).