Regulation of Sequential Release of Growth Factors for Cardiac Tissue Engineering

Bilayer nanoparticles regulate the release of multiple growth factors for cardiac regenerative medicine

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Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. In this study, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell have been developed for sequential GF release. Single and bilayer polymeric nanoparticles have been fabricated, characterized and biologically assessed. A novel ‘Geno-Neural model’ has been developed and validated for rate-programming of the nanoparticles. The bilayer nanoparticles feature low burst effect and time-delayed release, and allow for sequential release of PDGF following co-release of VEGF and bFGF, which have shown effective to promote angiogenesis in a cardiac patch hydrogel. The nanoparticulate delivery system, along with the Geno-Neural model, offers great potential for spatiotemporal control of GF release for cardiovascular regenerative medicine.


M. Izadifar, M.E. Kelly, X.B. Chen. NANOMEDICINE Vol. 11, No. 24, Pages 3237-3259 (2016).

Go to the profile of Mohammad Izadifar (Ph.D.)

Mohammad Izadifar (Ph.D.)

Cardiovascular Tissue Engineering, University of Toronto

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