Controlled mechanotransduction in therapeutic MSCs: can remotely controlled magnetic nanoparticles regenerate bones?
Free-to-access editorial on use of controlled magnetic nanoparticles for bone regeneration, written by James Henstock and Alicia El Haj
To inform cells of their physical environment, complex loading forces are transduced through tissue affecting homeostasis, regulation of cell behavior, differentiation and extracellular matrix composition.
Mechanotransduction is now developing into a recognized route for delivering tissue-forming stimuli to therapeutic cells. In an editorial in the latest issue of Regenerative Medicine (Volume 10 Issue 4), entitled ‘Controlled mechanotransduction in therapeutic MSCs: can remotely controlled magnetic nanoparticles regenerate bones?’, Alicia El Haj and James Henstock from Keele University Medical School, UK, discuss how these biomechanical pathways can be exploited to resolve long-standing challenges in regenerative medicine: the optimal construction, repair and integration of tissues in the body.
Read the full, free-to-access editorial here.