Treatment of perianal fistulas with human embryonic stem cell-derived MSCs: a canine model of human fistulizing Crohn's disease

Open access Research Article by Robert Lanza, Andrew Hoffman et al. presenting that canine models of refractory Crohn’s disease that receive a hESC-derived mesenchymal cell therapy undergo remission

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Oct 08, 2015
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Crohn's disease is a chronic inflammatory condition affecting millions. Current treatments are not always effective and patients often become refractory, leaving the patients in dire need of a new therapy. Canine anal furunculosis shares many features with Crohn’s disease and dogs have a physiology and immune system closely resembling humans, making them a good animal model for this condition.

Lluís Ferrer, Erin A Kimbrel, Andrea Lam, Elizabeth B Falk, Christine Zewe, Tarja Juopperi, Robert Lanza and Andrew Hoffman from Tufts Cummings School of Veterinary Medicine and Ocata Therapeutics (both MA, USA) have published an open access Research Article titled 'Treatment of perianal fistulas with human embryonic stem cell-derived MSCs: a canine model of human fistulizing Crohn's disease' demonstrating for the first time the safety and therapeutic potential of hESC-MSCs in a large animal model of human fistulizing Crohn’s disease.

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Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (, where you can find the aims and scope of the journal and details of our international editorial board.

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