IKVAV-linked cell membrane-spanning peptide treatment induces neuronal reactivation following spinal cord injury
New research looks at a novel treatment for spincal cord injury in vivo
In the latest publication from Future Science OA, John Enrique Mata and colleagues from Oregon State University (OR, USA) and Western University of Health Sciences (CA, USA) assess a novel membrane-spanning peptide (MSP) expressing the isoleucine-lysine-valine-alanine-valine (IKVAV) epitope in mice, following hemilaminectomy and compression injury. Following assessment of funcitonal improvement via mBB and spinal cord segments via histology, the researchers report significantly improved scores in IKVAV-MSP mice compared with control after 4 weeks, accompanied by a greater number of rotoplasmic astrocytes, neurons and muscle bundle size. They suggest that further research should be performed over a longer time period and in a greater number of animals to determine whether these improvements are maintained, and look forward to further work utilizing membrane-spanning peptides for presentation of bioactive molecules for stem cell therapy.
You can read the full, open access piece here.
Soheila Kazemi, Wendy Baltzer, Karl Schilke, Hadi Mansouri, John Enrique Mata. IKVAV-linked cell membrane-spanning peptide treatment induces neuronal reactivation following spinal cord injury. Future Sci. OA FSO81 doi:10.4155/fso.15.81 (2015).