Controlled Cultivation of Stem Cells – Factors to Consider When Thinking of Scale-Up

Great hopes and expectations are linked to stem cells as a tool for drug discovery and to stem cell-derived products in therapeutic applications.

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Nov 26, 2015
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Though several products have made it to commercial stage, most of the research is still performed in small scales using simple cultivation systems such as spinner flasks or T-flasks. Drug approval procedures however require a detailed knowledge of the process, reproducible results and a comprehensive documentation. At this point, the mentioned cultivation systems quickly reach their limits. To achieve production level yields these simple systems have limited economies of scale. Controlled bioreactors, widely established in traditional cell culture applications, can be the key to establish and optimize reproducible cultivation processes. Adapted to the special requirements of sensitive stem cells they provide a powerful tool for scale-up.

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Interested in learning about the challenges in developing cell culture consumables? Click here to view an interview with Eppendorf's Dr Daniel Wehrhahn, Director of the Cell Handling Applications.

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Eppendorf

Life sciences manufacturer, Biotechnology

Eppendorf is a leading life science company that develops and sells instruments, consumables, and services for liquid-, sample-, and cell handling in laboratories worldwide. Its product range includes pipettes and automated pipetting systems, dispensers, centrifuges, mixers, spectrometers, and DNA amplification equipment as well as ultra-low temperature freezers, fermentors, bioreactors, CO2 incubators, shakers, and cell manipulation systems. Consumables such as pipette tips, test tubes, microtiter plates, and single-use bioreactor vessels complement the range of highest-quality premium products. Eppendorf products are most broadly used in academic and commercial research laboratories, e.g., in companies from the pharmaceutical and biotechnological as well as the chemical and food industries. They are also aimed at clinical and environmental analysis laboratories, forensics, and at industrial laboratories performing process analysis, production, and quality assurance. Eppendorf was founded in Hamburg, Germany in 1945 and has more than 3,000 employees worldwide. The company has subsidiaries in 26 countries and is represented in all other markets by distributors. Eppendorf products are widely used within the cell culture workflow. This has been further expanded by the addition of new innovative cell culture consumables and small volume, multi vessel bioprocess systems.

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