Human adipose-derived stem cells promote vascularization of collagen-based scaffolds transplanted into nude mice

Open Access Research Article investigating whether human adipose-derived stem cells can support the vascularization of collagen-based implants transplanted into nude mice, by Mario Cherubino, Luigi Valdatta, Riccardo Balzaretti et al. from Università degli Studi dell'Insubria (Italy).

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May 18, 2016
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After in vivo implantation of cell-loaded medical devices, only the cells in closest proximity to the endogenous capillaries (100–200 μm) obtain sufficient nutrients to maintain their functions and survive, hampering the effectiveness of these implants. However, stem cells such as adipose-derived stem cells secrete factors that can support vasculogenesis. Therefore, Mario Cherubino, Luigi Valdatta, Riccardo Balzaretti et al. from Università degli Studi dell'Insubria (Italy) grafted mice with Bilayer and Flowable Integra® scaffolds, loaded with or without human adipose-derived stem cells in order to investigate the therapeutic potential of these cells to induce new vascular networks of engineered organs and tissues.

Cherubino M, Valdatta L, Balzaretti R et al. Human adipose-derived stem cells promote vascularization of collagen-based scaffolds transplanted into nude mice. Regen. Med (11)3, 261–271 (2016). Author for correspondence: rosalba.gornati@uninsubria.it.

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Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (www.future-science-group.com/journalprofile/regenerative-medicine/), where you can find the aims and scope of the journal and details of our international editorial board.

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