Development of a biomaterial associated with mesenchymal stem cells and keratinocytes for use as a skin substitute
Research Article investigating the characteristics of specially fabricated scaffolds aimed at use in wound healing applications, by Monica B Mathor, Bruna TS Santi, Dayane P Luco and Patricia Pranke (Brazil).
The use of scaffolds for regenerative medicine shows potential for supporting wound healing and regenerating damaged skin tissue, particularly for large burns and chronic wounds, where existing treatments often result in poor healing and significant scarring. In particular, a biocompatible and biodegradable scaffold at the lesion site would allow greater contact and interaction of cells at the injury site, and slow and steady degradation of the biomaterial could be important for regenerating damaged tissue.
This Research Article by Daniela Steffens, Monica B Mathor, Bruna TS Santi, Dayane P Luco and Patricia Pranke (Universidade Federal do Rio Grande do Sul, Instituto de Pesquisa com Células-tronco and Instituto de Pesquisas Energéticas e Nucleares, all Brazil) aimed to fabricate and characterize a cutaneous substitute combining mesenchymal stem cells, keratinocytes and an electrospun biomaterial comprised of poly-dl-lactic acid (PDLLA), hydrolyzed PDLLA (PDLLA/NaOH) or a PDLLA/NaOH scaffold linked to laminin protein, and see if the resulting scaffolds seem suitable for a wound healing application.
Steffens D, Mathor MB, Santi BTS, Luco DP, Pranke P. Development of a biomaterial associated with mesenchymal stem cells and keratinocytes for use as a skin substitute. Regen. Med. 10(8), 975–987 (2015).