Regenerating blood: towards engineering HIV-1-resistant hematopoietic stem cells

Free to access editorial from our latest Regenerative Medicine issue by Gero Hütter “...HIV‘1 gene therapy has opened the promise of a single shoot treatment that might replace, or at least amend, current antiretroviral lifelong treatment.” It has been now three decades since HIV‘1 was first recognized and nearly 20 years since combined antiretroviral therapy (HAART) improved the outcome of the infection effectively. However, although this success story has helped to transform HIV‘1 infection into a more chronic disease, there is still no vaccine or curative treatment available. Additionally, medicines to treat HIV‘1, particularly the newest and most tolerable drugs,...