Scaling human pluripotent stem cell expansion and differentiation: are cell factories becoming a reality?

Commentary by Morgan Alexander, Chris Denning, Asha K Patel et al. (University of Nottingham, UK) on the advances of human pluripotent stem cell derivatives being utilized within regenerative medicine and the options to overcome potential challenges in the future. Recent advances within regenerative medicine suggest that human pluripotent stem cells may soon be employed within clinical settings, prompting attempts to resolve the challenges involved in large-scale manufacture of cell therapies. Laboratory culture techniques cannot always translate into the clinical setting, meaning processes such as culture systems need to be developed for scaled-up manufacture. This Commentary by James GW Smith,, Adam...