Treatment of perianal fistulas with human embryonic stem cell-derived MSCs: a canine model of human fistulizing Crohn’s disease
Open access Research Article by Robert Lanza, Andrew Hoffman et al. presenting that canine models of refractory Crohn’s disease that receive a hESC-derived mesenchymal cell therapy undergo remission Crohn's disease is a chronic inflammatory condition affecting millions. Current treatments are not always effective and patients often become refractory, leaving the patients in dire need of a new therapy. Canine anal furunculosis shares many features with Crohn’s disease and dogs have a physiology and immune system closely resembling humans, making them a good animal model for this condition. LluÃs Ferrer, Erin A Kimbrel, Andrea Lam, Elizabeth B Falk, Christine Zewe, Tarja...