Physical and mechanical factors involved in tissue engineering of cartilage

Free to access Review by Carrie Gaut and Kiminobu Sugaya focuses on the effect that the different structural properties of scaffold can have on regulation of mesenchymal stem cell fate, and how this is currently being applied to cartilage tissue engineering research.

May 05, 2016

To date, tissue engineering approaches to treat osteoarthritis, an articular cartilage defects that has a significant and negative impact on the economy and quality of life worldwide, have mainly focused on stem cell proliferation and differentiation, and scaffolding. This Review by Carrie Gaut (Ciudad de Saber, Rep. de Panama) and Kiminobu Sugaya (University of Central Florida College of Medicine, FL, USA) discusses the properties to consider when tissue engineering cartilage.

Gaut C, Sugaya K. Critical review on the physical and mechanical factors involved in tissue engineering of cartilage. Regen. Med. 10(5), 665–679 (2015). Author for correspondence:

Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (, where you can find the aims and scope of the journal and details of our international editorial board.

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