Naive embryonic stem cells: the future of stem cell research?

Free editorial from our latest Regenerative Medicine issue by Carol Ware

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Sep 15, 2014

There are now two reports concerning de novo establishment of naïve human embryonic stem cells (hESC). The future value of naïve hESC hinges on what we now know about mouse (m) ESC. Two stages of mouse pluripotency have been stabilized to date through in vitro culture. “Naïve” represents the earliest stage, which can be enriched for a purer population, termed “ground state”. Naïve most closely approximates embryonic epiblast in the pre-implantation blastocyst. The primed state most closely approximates in vivo immediate post-implantation epiblast. There are clear differences between these stages in culture, expression, epigenetics (including appropriate X-inactivation) and developmental competence. The fact that naïve mESC can generate whole animals through tetraploid complementation while primed mESC cannot, is a particularly compelling reason for heightened expectations from naïve hESC.

By Carol Ware

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Regenerative Medicine

Journal, Future Science Group

Regenerative Medicine is an award-winning peer-reviewed journal, in print and web formats. The journal provides a forum to address the important challenges and advances in stem cell research and regenerative medicine, delivering this essential information in concise, clear and attractive article formats. Among other indexing services Regenerative Medicine is listed by MEDLINE/Index Medicus, EMBASE/Excerpta Medica, Chemical Abstracts, Science Citation Index Expanded™ (SciSearch®), Emcare, Biological Abstracts, BIOSIS Previews, Biotechnology Citation Index®, Journal Citation Reports/Science Edition®, Scopus® with an Impact Factor of 2.786 (2014). Each issue contains expertly drafted Reviews, Original Research articles, Perspectives, Editorials, topical insight from international leaders in their field, and additional added-value content. The Senior Editor of the journal is Professor Chris Mason, University College London. You can find out more about Regenerative Medicine at our website (, where you can find the aims and scope of the journal and details of our international editorial board.

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