Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes

Written by Adam Price-Evans

This Special Report article published in Regenerative Medicine evaluates whether there is evidence of a difference in regenerative capacity between stem cells taken from the young and elderly

This open access special report published in Regenerative Medicine written by Maria Teresa Gonzalez-Garza & Delia Elva Cruz-Vega (both Tecnológico de Monterrey, NL, México) discusses current published data and analyzes whether stem cells taken from elderly people have
the same regenerative capabilities as those from younger
people.

Abstract

The occurrence of chronic diseases such as neurological, metabolic and cardiovascular
degenerative disorders increases with age. Cell therapy is an emerging approach to the
treatment of these conditions. Of particular interest is the application of autologous
stem cells because it eliminates post-transplantation immune rejection and there are
less ethical concerns associated with their use. The regenerative capacity of stem cells
harvested from elderly people is however controversial. In this review, we analyze if
self-renewal potential, differentiation capability and expression of stemness genes in
stem cells collected from elderly patients validate their application in clinical trials and
examine the results.

Source

Gonzalez-Garza MT, Cruz-Vega DE. Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes. Regen. Med. 12(2), 169-178 (2017).


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