Research Article: Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine

Nanobiomaterials are also increasingly being recognized for their significant potential in targeted delivery of drug payloads, and particularly for drug delivery to inaccessible anatomical or intracellular compartments. This is indicated in an original article in the Special Focus Issue ‘Engineering the nanoenvironment for regenerative medicine’ by Schiavi et al., who present research on a new generation of collagen nanofiber implants functionalized with BMP-7 nanoreservoirs and equipped with human mesenchymal stem cell microtissues for regenerative nanomedicine. Aims: Mesenchymal stem cells (MSCs) from adult bone marrow provide an exciting and promising stem cell population for the repair of bone in skeletal diseases....