Aligned nanofibers direct human dermal fibroblasts to tenogenic phenotype in vitro and enhance tendon regeneration in vivo

Research Article investigating the effect of aligned nanofibers on de novo rat Achilles tendon regeneration in vivo, by Wenbo Wang, Jing He, Wei Liu et al. from Shanghai Jiao Tong University and Tongji University School of Medicine (both Shanghai, PR China). Nanofibers have become an important biomaterial for tissue engineering and regenerative medicine owing to their structure mimicking that of the extracellular matrix and ease of forming certain topographical structures. Dermal fibroblasts are a common cell type participating in connective tissue repair that have been demonstrated as being capable of being used for in vitro and in vivo tendon engineering....