Could stem cell conditioning improve treatment for low back pain?

Kolling Institute (Australia) researchers examine the use of FGF-2 and FGF-18 to direct mesenchymal stem cells for spinal repair

Like 0 Comment

While the WHO indicated that intervertebral disc (IVD) degeneration be a high-priority research area as long ago as 1999, it remains the top global musculoskeletal disorder, affecting many worldwide. As such, research into this area remains a priority.

Stem cells have shown some promise in this area. As a result, Cindy Shu and colleagues at the Raymond Purves Bone & Joint Research Laboratory (Kolling Institute, NSW, Australia) investigated conditioning of mesenchymal stem cells (MSCs) in a bid to improve their efficacy for low back pain treatment.

Using MSCs isolated from adult ovine bone marrow, they stimulated the stem cells with FGF-2 and -18 and examined their effects on chondrogenic and osteogenic differentiation in vitro. These particular growth factors both effect chondrogenesis.

With FGF-18 resulting in earlier chondrogenesis than FGF-2, both produced cell lineages with increased chondrogenesis and osteogenesis.

"The major conclusions from this study were that FGF-2 and -18 promoted chondrogenic differentiation of marrow-derived chondroprogenitor cells early in pellet culture with FGF-2 promoting matrix production and cellular proliferation, while FGF-18 delayed hypertrophy and also supported expression of osteogenic genes," noted the authors. "Selective induction of such MSC lineages may well be of application in regenerative strategies maximizing matrix replenishment (FGF-2 lineages) and osteo-integration/osteogenesis (FGF-18 lineages) in tensional and weight-bearing connective tissues such as the spine."

You can read the full study in full here.

Shu C, Smith SM, Little CB, Melrose J. Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages. Future Sci. OA FSO142 doi:10.4155/fsoa-2016-0034 (2016).

Go to the profile of Future Science OA

Future Science OA

Open Access Journal, Future Science Group

Future Science OA is an online, open access (CC-BY), peer-reviewed title from Future Science Group. The journal’s broad coverage includes all areas of biotechnology and medicine, as well as topics in biological, life and physical sciences that are of relevance to human health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of medical science. All original research articles that have been conducted with scientific rigor and research integrity will be considered. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis.

No comments yet.