Examining the effects of preoperative medication in regenerative dental medicine

New study investigates the osteoinductive effects of dexamethasone during primary cell culture of human dental pulp stem cells

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Apr 12, 2017
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A new study from Silvio Duailibi and colleagues at UNIFESP (Brazil) has assessed the osteoinductive effect of dexamethasone (DEX) administered as a preoperative medication in primary cell culture of human dental pulp stem cells (hDPSCs).

During tooth extraction for third molar cell culture, preoperative medication might be used to reduce trauma and pain. DEX is a long-acting steroid used as an anti-inflammatory administered around 1 hour prior to surgery. Furthermore, DEX is known to induce osteoblast differentiation of mesenchymal stem cells and osteogenic development, and is used in culture media.

Commenting on the aims of the study, the authors noted: "it is important to know whether this drug, when orally administered, will produce the same osteoinductive effect as when it is added directly to culture media. In this context, the aim of this study was to evaluate the osteoinductive effect of DEX when administered as a preoperative medication in primary cell culture of dental pulp."

Their results, available open access in Future Science OA, demonstrated an effect of DEX on hDPSCs, resulting in cell differentiation within 14 days in culture. This preliminary research highlights the need to fully understand the effect of DEX in cell culture following surgery, and indeed to expand similar research to other drugs.

Osteoinductive effects of preoperative dexamethasone in human dental pulp stem cells primary culture
Rani da Cunha Moretti, Monica Talarico Duailibi, Paulo Oliveira Martins, Jennifer Adriane dos Santos, Silvio Eduardo Duailibi
Future Science OA, FSO184 doi:10.4155/fsoa-2016-0083 (2017).

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Open Access Journal, Future Science Group

Future Science OA is an online, open access (CC-BY), peer-reviewed title from Future Science Group. The journal’s broad coverage includes all areas of biotechnology and medicine, as well as topics in biological, life and physical sciences that are of relevance to human health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of medical science. All original research articles that have been conducted with scientific rigor and research integrity will be considered. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis.
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