Integration concepts for multi-organ chips: how to maintain flexibility?!

In this Future Science OA perspective, learn about designing flexible platforms for drug development and disease modelling.

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Feb 07, 2018
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Multi-organ platforms have an enormous potential to lead to a paradigm shift in a multitude of research domains including drug development, toxicological screening, personalized medicine as well as disease modeling. Integrating multiple organ–tissues into one microfluidic circulation merges the advantages of cell lines (human genetic background) and animal models (complex physiology) and enables the creation of more in vivo-like in vitro models

"Together, the technology will help to significantly reduce the use of animal models in the coming years and may lead to an animal-testing free R&D in the distant future"

In recent years, a variety of design concepts for multi-organ platforms have been introduced, categorizable into static, semistatic and flexible systems. This perspective elucidates the concept of ‘mix-and-match’ toolboxes and discusses the numerous advantages compared with static/semistatic platforms as well as remaining challenges.

Rogal J, Probst C, Loskill P. Integration concepts for multi-organ chips: how to maintain flexibility?! Future Sci. OA. 3(2), FSO180 (2017)

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Future Science OA

Open Access Journal, Future Science Group

Future Science OA is an online, open access (CC-BY), peer-reviewed title from Future Science Group. The journal’s broad coverage includes all areas of biotechnology and medicine, as well as topics in biological, life and physical sciences that are of relevance to human health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of medical science. All original research articles that have been conducted with scientific rigor and research integrity will be considered. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis.

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