IKVAV-linked cell membrane-spanning peptide treatment induces neuronal reactivation following spinal cord injury

New research looks at a novel treatment for spincal cord injury in vivo In the latest publication from Future Science OA, John Enrique Mata and colleagues from Oregon State University (OR, USA) and Western University of Health Sciences (CA, USA) assess a novel membrane-spanning peptide (MSP) expressing the isoleucine-lysine-valine-alanine-valine (IKVAV) epitope in mice, following hemilaminectomy and compression injury. Following assessment of funcitonal improvement via mBB and spinal cord segments via histology, the researchers report significantly improved scores in IKVAV-MSP mice compared with control after 4 weeks, accompanied by a greater number of rotoplasmic astrocytes, neurons and muscle bundle size. They...