Welcome to our spotlight on organoids!
Quick access to all the content in the latest RegMedNet spotlight, including expert editorials, peer-reviewing journal content and more.
Organoids offer a unique opportunity to model drugs and diseases in vitro; these 3D cell cultures comprise of a range of organ-specific cell types and are closely biomimetic, enabling more accurate drug testing and disease modelling than traditional 2D cultures. They can be grown from a range of cell types, including human and murine embryonic stem cells (SCs), pluripotent SCs and other adult SCs.
However, they are not without inaccuracy. Without vasculature, their ability to mature and sustain themselves is limited, and some organoids may lack key cells types. Organoids developed from human embryonic SCs are also subject to the same intense debate around the ethics of utilizing these cells.
This spotlight will aim to review technological developments that have allowed organoids to become a viable research tool as well as remaining challenges in their production. We will also cover the varied applications for which organoids could be utilized, and investigate what the future could hold for organoids in research and clinical translation.
Visit the spotlight - new posts weekly!
Editorials and interviews
- Recombinant Laminin-511 E8 fragments, an innovative cell culture matrix
- Highest stability recombinant Wnt3a for organoid culture
- New service available for the screening of limited human cancerous tissue in 3D
- Organoids: a revolution in in vitro mammalian cell culture
- RegMedNet exclusive: The advantages of bioprinting for organoid production: an interview with Yu Shrike Zhang
- RegMedNet exclusive: Next generation neural microphysiological systems: advances, applications, challenges and opportunities
- RegMedNet exclusive: The importance of patient-specific models: an interview with Stephanie Seidlits
- RegMedNet exclusive: Using organoids to identify new therapeutics: an interview with James Hudson
- RegMedNet exclusive: “Different culture systems for different purposes”: an interview with Dik van Gent
- RegMedNet exclusive: Creating 3D ‘asteroids’: neural stem cell organoids
- Share your thoughts on organoids and you could win an Amazon voucher!
- RegMedNet exclusive: The organoid revolution: an interview with Amritha Jaishankar
- RegMedNet exclusive: Regenerating thyroid and lung function through differentiated iPSCs: an interview with Darrell Kotton
- Ex vivo tumor culture systems for functional drug testing and therapy response prediction
- Integration concepts for multi-organ chips: how to maintain flexibility?!
- Roche and Takeda to invest in organ-chip development
- New method for high-volume production of engineered gut and liver tissue
- MDI Biological Laboratory launches new signature course on organoid technology
- Artificial human bile ducts rebuild biliary tree in murine model
- The rule of three: a trisection approach to in vitro retinal generation
- Disease-modeling mini-kidney organoids successfully grown in vitro
- Physics sheds light on stem cell-derived organoid growth and brain development