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Osteogenic, adipogenic and chondrogenic differentiation of MSCs

In this infographic, Alice Philipson (University of Leeds, UK) provides an overview of different pathways of differentiation for MSCs.

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May 04, 2018

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Go to the profile of James L. Sherley, M.D., Ph.D.
James L. Sherley, M.D., Ph.D. almost 2 years ago

A more accurate depiction of these populations would show a small fraction of asymmetrically self-renewing stem cells that divide to produce committed progenitors that accumulate to much higher fraction than the stem cells.  Thereafter, the relationships between the pathways to different differentiation lineages is rather ill-defined.  However, it may be that most committed progenitors can be directed along any of the three described differentiation paths depending on the environmental factors supplemented.  The important correction in knowledge is that described MSC populations, no matter their tissue of origin, are never homogeneous stem cell populations as they are so often erroneously depicted and treated.