Ex vivo tumor culture systems for functional drug testing and therapy response prediction

Written by Future Science OA

In this Future Science OA review, learn more about different models for drug testing and how to select the most suitable one for your application.

“Selecting the right model system for the right purpose is at least as important as developing new and improved culture systems”

Optimal patient stratification is of utmost importance in the era of personalized medicine. Prediction of individual treatment responses by functional ex vivo assays requires model systems derived from viable tumor samples, which should closely resemble in vivo tumor characteristics and microenvironment. This review discusses a broad spectrum of model systems, ranging from classic 2D monolayer culture techniques to more experimental ‘cancer-on-chip’ procedures. 

Find out more: “Different culture systems for different purposes”: an interview with Dik van Gent

Meijer TG, Naipal KAT, Jager A, van Gent DC. Ex vivo tumor culture systems for functional drug testing and therapy response prediction. Future Sci. OA. 3(2), FSO190 (2017)