Human adipose-derived stem cells promote vascularization of collagen-based scaffolds transplanted into nude mice

Open Access Research Article investigating whether human adipose-derived stem cells can support the vascularization of collagen-based implants transplanted into nude mice, by Mario Cherubino, Luigi Valdatta, Riccardo Balzaretti et al. from Università degli Studi dell'Insubria (Italy). After in vivo implantation of cell-loaded medical devices, only the cells in closest proximity to the endogenous capillaries (100—200 μm) obtain sufficient nutrients to maintain their functions and survive, hampering the effectiveness of these implants. However, stem cells such as adipose-derived stem cells secrete factors that can support vasculogenesis. Therefore, Mario Cherubino, Luigi Valdatta, Riccardo Balzaretti et al. from Università degli Studi dell'Insubria (Italy)...