Hydrostatic pressure promotes endothelial tubulogenesis

Researchers from Tokyo University of Agriculture and Technology (Tokyo, Japan) have discovered a mechanism by which the endothelial cells lining the inside of blood vessels are stimulated. The findings, published in Communications Biology, may lead to new treatments to help regenerate blood vessels in degenerative diseases. The team studied how endothelial cells lining the inside of blood vessels regenerated in response to hydrostatic pressure. "Blood vessels are constantly exposed to stimuli such as fluid shear stress, cyclic tensile force and hydrostatic pressure," explained. Daisuke Yoshino (Tokyo University of Agriculture and Technology). "Although the detailed mechanisms about cellular responses to shear...