Influence of porosity and pore shape on structural, mechanical and biological properties of poly ϵ-caprolactone electro-spun fibrous scaffolds

Written by Nanomedicine

Research Article investigating the effects of porosity and pore shape on the properties of electrospun scaffolds, by Kieran P Fuller, Diana Gaspar, Luis M Delgado, Abhay Pandit, Dimitrios I Zeugolis (NUI Galway, Galway, Ireland).

Tissue engineered, regenerative therapies will likely require appropriate structural support as well as biomimicry for cell modulation. There are many different approaches for scaffold fabrication, including top-down (e.g., lithography, laser etching, imprinting), bottom-up (e.g., self-assembly, direct writing, melt-spinning, 3D printing, electro-spinning), and nano- and micro-fabrication techniques, but to date a detailed study on the influence of pore shape and porosity on structural, physical and biological properties of electrospun scaffolds has not yet been carried out.

This Research Article by Kieran P Fuller, Diana Gaspar, Luis M Delgado, Abhay Pandit, Dimitrios I Zeugolis (NUI Galway, Galway, Ireland) aimed to analyze the effect of predefined collector architecture (variable pore shape and porosity) on the structural, mechanical (tensile and ball burst) and biological (dermal fibroblast and THP-1) properties of electrospun scaffolds.

Fuller KP, Gaspar D, Delgado LM, Pandit A, Zeugolis DI. Influence of porosity and pore shape on structural, mechanical and biological properties of poly ϵ-caprolactone electro-spun fibrous scaffolds. Nanomedicine (Lond.) 11(9), 1031—1040 (2016).