Clinical applications of induced pluripotent stem cell-mediated therapies in cancer: progress, challenges, and future directions
Summary
ABSTRACT Induced pluripotent stem cells (iPSCs) have emerged as a transformative platform for developing innovative therapies against hematological malignancies. Their pluripotent nature allows differentiation into functional immune effector cells, enabling the generation of iPSC-derived chimeric antigen receptor (CAR)-T and CAR-natural killer (NK) cells as scalable “off-the-shelf” immunotherapies that overcome donor limitations and immune rejection. These engineered immune cells exhibit improved specificity, persistence, and cytotoxicity against leukemia and lymphoma. Moreover, iPSCs hold great promise in regenerative hematology, as they facilitate bone...