Comparative study of the effects of subcutaneously administered umbilical cord-derived mesenchymal stem cells and exosomes derivatives on wound healing in a chemical burn model of alkaline-induced skin burns
Summary
ABSTRACT Background In burn-injured skin, the main goal is to accelerate wound healing and restore the barrier. In chemical burns, excessive inflammation and deep tissue damage complicate repair. Regenerative medicine approaches may modulate these processes. This study investigated the effects of human umbilical cord-derived mesenchymal stem cells (HucMSCs) and their exosomes (Exo-HucMSCs) on wound healing in a chemical burn model. Methods A chemical burn was induced on the dorsal skin of 24 Wistar rats using 2 M sodium hydroxide. Rats were...