Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors
This original research article details the use of computational fluid dynamics modeling to investigate the ability of vertical-wheel bioreactors to overcome challenges associated with the scale up of cell and gene therapies.
Find out how a vertical-wheel mechanism affects the hydrodynamics of a bioreactor and the subsequent implications for hiPSC expansion, and discover how these systems perform alongside a single-cell inoculation strategy under a variety of feeding regimens.
To learn more about this innovative technology, visit PBS Biotech.
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