Process modeling and optimization of a cell therapy manufacturing operation

Written by Regenerative Medicine

Commentary discussing how process modeling tools aimed at optimizing large-scale manufacturing can be used by the cell therapy industry to maximize output, effectively manage resources and minimize cost of goods, by Maria E Chisholm and Daniel J Hopkins (LGC Limited, UK).

The manufacture of cell-based therapies is expensive as it requires specialized, high-category clean room facilities that provide the necessary sterile and controlled environment for successful culture and processing. In order for products to be commercially viable, their manufacture needs to be lower cost, meaning ways to optimize processes need to be identified.

Figure 1.‚ Schematic diagram indicating the key stages of the cell culturing process.

This Commentary by Maria E Chisholm and Daniel J Hopkins (LGC Limited, UK) discusses how a computation tool, discrete event simulation, can be used to help predict resource requirements and optimize manufacturing operations, presenting a case study where the tool was applied in a real cell therapy manufacturing environment.

Chisholm ME, Hopkins DJ. Process modeling and optimization of a cell therapy manufacturing operation. Regen. Med. 9(4), 427—430 (2014).
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