This Epigenomics Research Article analyzes the DNA methylation and transcriptomic profiles of murine embryo dorsal skin to help understand why fetus’ capacity for scarless wound healing is lost during gestation. By Justyna Podolak-Popinigis, Anna Ronowicz, Monika Dmochowska, Agnieszka Jakubiak and PaweÅ‚ Sachadyn from GdaÅ„sk University of Technology (Poland).
Extensive DNA methylation and gene expression changes occur during fetal skin development following the decline of scarless healing after day 15 of gestation. Therefore, this Epigenomics Research Article by Justyna Podolak-Popinigis, Anna Ronowicz, Monika Dmochowska, Agnieszka Jakubiak and PaweÅ‚ Sachadyn from GdaÅ„sk University of Technology (Poland) investigated the DNA methylation changes in the in mouse fetus dorsal skin in the period before and after the scarless healing capacity is lost in order to identify new candidate genes involved in the process.
Podolak-Popinigis J, Ronowicz A, Dmochowska M, Jakubiak A, Sachadyn P. The methylome and transcriptome of fetal skin: implications for scarless healing. Epigenomics doi:10.2217/epi-2016-0068 (2016) (Epub ahead of print).