The translation of cell-based therapies: clinical landscape and manufacturing challenges

An Open Access Review by Christopher J Hewitt, Alvin W Nienow, Mark J McCall et al. (Loughborough University and FUJIFILM Diosynth Biotechnologies, both UK) providing a comparative assessment of the current technologies being utilized to manufacture cell-based therapies. Cell-based therapies have great potential to be utilized within clinical treatment, as such it is essential for effective manufacture of these products; however, challenges remain in defining their requirements. This Review by Thomas RJ Heathman, Alvin W Nienow, Mark J McCall, Karen Coopman, Bo Kara and Christopher J Hewitt from Loughborough University and FUJIFILM Diosynth Biotechnologies (both UK) identifies the challenges associated...