The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care

Written by Regenerative Medicine

Special Report by Ian L Valerio et al. ( Wexner Medical Center of the Ohio State University, OH, USA) reporting the findings of a retrospective review of traumatic and combat casualty cases at Walter Reed National Military Medical Center, which utilized urinary bladder matrix in the wound care and reconstruction of various traumatic and combat-related wounds.

Treatment of combat injuries and resulting wounds can be difficult to treat due to compromised and evolving tissue necrosis, environmental contaminants, multidrug-resistant microbacterial and/or fungal infections, coupled with microvascular damage and/or hypovascularized exposed vital structures. This Special Report by Ian L Valerio, Paul Campbell, Jennifer Sabino, Christopher L Dearth and Mark Fleming discusses surgical care algorithms developed by their group to achieve stable, definitive wound coverage utilizing urinary bladder matrix, which has demonstrated the capacity to facilitate definitive soft tissue reconstruction by establishing a neovascularized soft tissue base acceptable for second-stage wound and skin coverage options within traumatic and combat-related wounds.

Valerio IL, Campbell P, Sabino J, Dearth CL, Fleming M. The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care. Regen. Med. 10(5), 611—622 (2015).

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