Treatment of perianal fistulas with human embryonic stem cell-derived MSCs: a canine model of human fistulizing Crohn’s disease

Written by Regenerative Medicine

Open access Research Article by Robert Lanza, Andrew Hoffman et al. presenting that canine models of refractory Crohn’s disease that receive a hESC-derived mesenchymal cell therapy undergo remission Crohn’s disease is a chronic inflammatory condition affecting millions. Current treatments are not always effective and patients often become refractory, leaving the patients in dire need of a new therapy. Canine anal furunculosis shares many features with Crohn’s disease and dogs have a physiology and immune system closely resembling humans, making them a good animal model for this condition. Lluís Ferrer, Erin A Kimbrel, Andrea Lam, Elizabeth B Falk, Christine Zewe, Tarja...

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