Use of bioartificial dermal regeneration template for skin restoration in combat casualty injuries

Written by Regenerative Medicine

Special Report on the use of bioartificial dermal regeneration templates in the management of complex soft tissue war wounds by Jonathan G Seavey et al. (Walter Reed National Military Medical Center, Bethesda, MD, USA), and letter in response by Franck Marie Leclère and Vincent Casoli (University of Bordeaux, France).

War injuries are often complex composite defects devoid of well-vascularized tissue in critically ill patients, which require serial surgical debridements to remove necrotic, contaminated and compromised tissue. Bioartificial dermal regeneration templates (DRTs) may facilitate vascularization and formation of a neodermis, and are playing an increasing role in the treatment of traumatic war wounds.

In a Special Report by Jonathan G Seavey, Zachary A Masters, George C Balazs, Scott M Tintle, Jennifer Sabino, Mark E Fleming and Ian L Valerio from institutes including the Walter Reed National Military Medical Center (Bethesda, MD, USA), the authors present their experience in applying bioartificial DRTs for coverage of full-thickness traumatic wounds as an adjunct to traditional soft tissue reconstructive procedures, and conclude that efforts should be made to promote and develop the use of dermal substitute for complex plastic surgery reconstruction.

In a letter in response, Franck Marie Leclère and Vincent Casoli from University of Bordeaux (France) discuss their thoughts on the study and provide the advantages and disadvantages they have observed in regards to the use of dermal substitutes for complex plastic surgery reconstruction.

Access both of these articles below:

Special Report

Seavey JG, Masters ZA, Balazs GC, Tintle SM, Sabino J, Fleming ME, Valerio IL. Use of a bioartificial dermal regeneration template for skin restoration in combat casualty injuries. Regen. Med. 11(1), 81—90 (2016).

Author for correspondence: [email protected]

Letter to the Editor

Leclère FM, Casoli V. Use of bioartificial dermal regeneration template for skin restoration in combat casualty injuries. Regen. Med. 11(4), 359—360 (2016).

Author for correspondence: [email protected]; [email protected]