G-CSF enhances the therapeutic potency of stem cells transplantation in spinal cord-injured rats

Written by RegMedNet
Basic research Cell therapy Journal articles

In this article, human wisdom teeth-derived neuronal stem cell treated with granulocyte-colony-stimulating factor were evaluated for contusion-induced spinal cord injury in rats.

Published in Regenerative Medicine, Pang and colleagues (Tzu Chi University of Science & Technology, Hualien, Taiwan) investigated whether G-CSF could be utilized to enhance the regenerative ability of neuronal stem cell transplantation in rats. By transplanting neuronal stem cells into rats with spinal cord injuries, the team hoped to show a greater effect on recovery with G-CSF treatment. Following their fascinating results in rats, the team have supported their work with further in vitro assessment of the cells and interaction with the cytokine.

Aim: The team investigated the therapeutic effects of human wisdom teeth-derived neuronal stem cell (tNSC), treated with granulocyte-colony-stimulating factor, in regenerating contusion-induced spinal cord injury in rats.

Materials and methods: 7 days after contusion, neuronal stem cells were transplanted to the injury site. Following the transplantion, G-CSF treatment was conducted for 5 days. After treatment behavioral deficits were evaluated by the Basso, Beattie and Bresnahan test and the injury site was collected for immunohistochemistry analysis.

Continue reading the article in Regenerative Medicine, free exclusively for RegMedNet members >>

Have any additional questions about this story? Ask us in the comments, below.

Find out more in these top picks from the Editor: