Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization

Written by Nanomedicine

Research Article by Quentin Wagner, Damien Offner, Laetitia Keller et al. from INSERM (France) investigating seeking to develop a nanoactive implant that improves endothelial cell activity for bone tissue engineering and regenerative medicine applications.

A significant barrier to successful restoration of tissues or organs within the field of tissue engineering and regenerative medicine is the integration of functional vascular systems with implants. Biomaterials based on the micro- and nano-scale environment of tissues with biological components are in investigation for improved repair: for example, bone substitutes can contain bone-growth factors such as BMPs, and angiogenic factors such as VEGF and Ang1.

In this Research Article, Quentin Wagner, Damien Offner, Laetitia Keller et al. from INSERM (France), Liverpool John Moores University (UK) and UCL (London, UK) present their investigations in developing a nanoparticle scaffold with both HUVECs and VEGF to improve vasculatization of bone implants.

Wagner Q, Offner D, Idoux-Gillet Y et al. Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization. Nanomedicine 11(18), 2419—2430 (2016).

Poster image reproduced with permission from Nanomedicine 11(18), 2419—2430 (2016).