Breakthrough in DNA delivery: modified lipid nanoparticles enable safer gene expression
Researchers have modified lipid nanoparticles (LNPs) that can safely deliver plasmid DNA in mice, enabling long-lasting gene expression and overcoming key challenges in DNA-based genetic therapies.
Scientists from the Perelman School of Medicine at the University of Pennsylvania (PA, USA) have developed a novel strategy to overcome key limitations in delivering DNA using LNPs. This breakthrough enables safer transgene expression and could significantly advance the field of genetic medicine. The improved process was recently published in Nature Biotechnology.
