CRISPR for cancer: targeting cancer-specific genes in solid tumors

Written by Lucy Welsh (Contributing Editor)
Cancer Gene editing Gene therapy News Preclinical research

Targeted CRISPR lipid nanoparticles eliminated 50% of tumors in mice with head and neck cancer.

Researchers from Tel Aviv University (Israel), led by Razan Masarwy, have investigated utilizing CRISPR in lipid nanoparticle (LNP) delivery systems to target cancer-specific genes in head and neck cancers. By cutting out an essential cancer gene, 50% of tumors were successfully eliminated from in vivo mouse models, indicating the potential of targeted CRISPR-LNP delivery systems for cancer treatment.

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Source

  1. Masarwy R, Breier D, Stotsky-Oterin L <i>et al.</i> Targeted CRISPR/Cas9 Lipid Nanoparticles Elicits Therapeutic Genome Editing in Head and Neck Cancer. <i>Adv. Sci.</i> 12(7), e2411032 (2024).

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