Components of amniotic allograft revealed to help better understand acceleration of wound healing

Written by RegMedNet

A study by MiMedx Group, Inc. (Marietta, GA, USA) has identified the components of micronized, dehydrated human amnion/chorion membrane grafts, leading to enhanced understanding of how they can be used to promote wound healing.

A research team from MiMedx Group, Inc. (Marietta, GA, USA) led by Thomas J Koob has identified the components and biological factors of an allograft utilized to promote wound repair, helping to explain the mechanisms by which the graft supports repair.

Physiological wound healing involves a coordinated sequence of events involving signaling and remodeling of the extracellular matrix (ECM) and is generally achieved by progression through the distinct phases of hemostasis, inflammation, proliferation and remodeling. Interference with this process can result in impaired tissue repair, which causes a significant burden to patients and the healthcare system, meaning a more effective therapy is required.

The amniotic membrane is a widely exploited ECM tissue in wound healing applications due to its growth factor/cytokine enrichment and its dynamic nature, which allows it to coordinate ECM remodeling. The MiMedx team evaluated the concentrations and distribution of ECM components, growth factors, matrixmetalloproteinases and their inhibitors in the PURION® Processed dehydrated human amnion/chorion membrane allograft to explore the micronized form of the tissue and enhance the understanding of how amniotic membrane therapies can be utilized to promote wound repair.

“We believe that at an injury site, the administration of MiMedx micronized dHACM tissue will deliver matrix molecules, a cocktail of growth factors and cytokines, and protease inhibitors that collectively promote healing. Ultimately, the use of MiMedx micronized dHACM in the treatment of chronic wounds may advance the current standards of wound care,” stated Koob.

— Written by Adam Price-Evans

Sources: Lei J, Priddy LB, Lim JL, Massee M, Koob TJ. Identification of extracellular matrix components and biological factors in micronized dehydrated human amnion/chorion membrane. Adv. Wound Care (New Rochelle) doi:10.1089/wound.2016.0699 (2016) (Epub ahead of print);