Development of 3D-printed acoustic holograms could allow personalized treatment in patients with neurological diseases

A research team based at Universitat Politècnica de València (UPV, Spain) and the Consejo Superior de Investigaciones Cientificas (CSIC, Madrid, Spain) have successfully 3D-printed holograms that could transform drug delivery through the blood–brain barrier in patients with neurological diseases, such as Alzheimer’s or Parkinson’s disease. Focused ultrasounds hold significant potential in treating neurological diseases due to their precise and non-invasive qualities. However, applying them to the central nervous system has historically been difficult due to the effects of aberration and attenuation of the skull and the intricate and extensive spatial distribution of the deep structures in the brain. Now, 3D-printed...