Effectiveness of CAR-T therapy could be indicated by presence of stem cell memory T cells

Having studied the effectiveness of CAR-T therapies in children with leukemia, researchers and clinicians at University College London (UCL) and Great Ormond Street Hospital (both London, UK) have discovered a subset of T cells that are likely to contribute to the success of the treatment. The study has been published in Nature Cancer. "During clinical trials we have seen some very encouraging results in young patients with leukemia, however it's still not clear why CAR T-cells continue to be present in the long-term for some patients, stopping the cancer from returning, while others remain at a high risk of relapse,”...